A Significant Increasing Risk Association between Cigarette Smoking and XPA and XPC Genes Polymorphisms

Cigarette smoking (CS) is a major cause of various serious diseases due to tobacco chemicals. There evidence suggesting that CS has been linked with the DNA damage repair system, as it can affect genomic stability, inducing genetic changes in genes involved specifically nucleotide excision (NER) pathway, affecting function and/or regulation these genes. Single polymorphism (SNP), along CS, work NER pathway and, therefore, could lead different diseases. This study explored association four SNPs both XPA and XPC Saudi population. The Taq Man genotyping assay was used for 220 healthy non-smokers (control) 201 smokers evaluate gene named rs10817938, rs1800975, rs3176751, rs3176752 called rs1870134, rs2228000, rs2228001, rs2607775. In gene, SNP rs3176751 showed high-risk CS-induced all clinical parameters, including duration, intensity, gender, age smokers. On other hand, rs1800975 statistically significant low-risk parameters. addition, rs10817938 only long-term younger A found older rs2228001 female rs2607775 revealed diseases, concerning except male However, rs2228000 rs1870134 no CS. Overall, results demonstrated possible associations (effector/and protector) between polymorphisms genes, such XPC, polymorphisms.